Up-LIFT pivotal trial of ARC-EX improves arm and hand function in chronic tetraplegia (Nature Medicine)

ONWARD Medical/ARC Therapy (ARC-EX / ARC-IM / ARC-BCI)

ONWARD Medical's Up-LIFT pivotal trial results published in Nature Medicine showed that transcutaneous spinal cord stimulation via ARC-EX, applied during rehabilitation, met its primary endpoint with no serious adverse events. 72% of the 60-person trial cohort improved in both arm strength and functional hand use; 90% improved in at least one metric.

• Primary endpoint met: no serious adverse events related to therapy; 72% of 60 participants exceeded minimal important difference in both strength and function.
• Safety and efficacy: 87% reported improved quality of life; improvement sustained after average 25 stimulation sessions; non-invasive surface electrode delivery.
• Complements rather than replaces physical rehabilitation; particularly effective for hand and arm function in cervical spinal cord injury.