Vega HiFi Long-Read Sequencing by Pacific Biosciences (PacBio): status and timeline

Vega HiFi Long-Read Sequencing

Make long-read HiFi sequencing accessible to smaller research groups and clinical labs with simpler workflows and lower sample requirements.

DeployStage 4 of 5

SPRQ-Nx chemistry (Aug 2026): 90 Gb per run, 40% lower per-gigabase cost, 500 ng DNA input.

Updated 5 Aug 2026Checked 11 Oct0 updates this week

Milestones

No announced next step

Vega system launched2025Complete.
SPRQ-Nx chemistry released with 90 Gb/run and 40% cost reduction5 Aug 2026Complete.

Most important, last 3 months

PacBio announces Vega SPRQ-Nx chemistry: 90 Gb per run at 40% lower cost, 500 ng DNA input5 Aug 2026

How it works

2 parts

Benchtop design

Compact long-read sequencer

Vega brings SMRT sequencing to smaller labs in a compact footprint, using the same HiFi technology as Revio.

SPRQ-Nx chemistry

Chemistry reduces input and cost

SPRQ-Nx (Aug 2026) lowers DNA input from 2 µg to 500 ng, increases output to 90 Gb per run, and cuts per-gigabase cost 40%.

Spec sheet

Spec	Vega HiFi Long-Read Sequencing
Data per run (SPRQ-Nx)	90 Gb^R (reported)
List price per run (SPRQ-Nx)	$995^R (reported)
DNA input requirement (SPRQ-Nx)	≤500 ng^R (reported)
Consensus accuracy	>99.9%^R (reported)

^R reported by the company

Update log

1 update

Wed 5 Aug

Major: PacBio announces Vega SPRQ-Nx chemistry: 90 Gb per run at 40% lower cost, 500 ng DNA inputPressHardware

About Pacific Biosciences (PacBio)

The team behind Vega HiFi Long-Read Sequencing

Pacific Biosciences (PacBio)

Long-read DNA sequencing, HiFi, Revio, Vega

Pacific Biosciences develops and manufactures long-read DNA sequencing systems. The company's HiFi technology combines the long-read coverage of its systems with high accuracy, enabling whole-genome and targeted sequencing for research and clinical applications. PacBio is publicly traded on Nasdaq.

PacBio's HiFi long-read sequencing captures structural variants and repeats that short-read sequencers miss.
Revio handles high-throughput research; Vega is a benchtop system for smaller labs with lower DNA input.
Vega SPRQ-Nx chemistry (Aug 2026): 90 Gb per run, 40% lower cost, 500 ng DNA input vs. 2 µg prior.

pacb.com (opens pacb.com)Company profile →

Founded: 200422 yrs
Headquarters: United States
Status: Public
Listed: PACB (opens google.com)NASDAQ
Valuation: public
Staff: ~575Oct 2024
Works in: BiotechGenomics & sequencing
Coverage: 2 programs · 1 updatelatest 5 Aug 2026checked 11 Oct
People: Mark Van Oene (opens investor.pacb.com)President and Chief Executive Officer

Spec

Vega HiFi Long-Read Sequencing

Data per run (SPRQ-Nx)

90 Gb^R (reported)

List price per run (SPRQ-Nx)

$995^R (reported)

DNA input requirement (SPRQ-Nx)

≤500 ng^R (reported)

Consensus accuracy

>99.9%^R (reported)