NewLimit reports 11 more gene-switch sets that restore youthful function in aged T cells

NewLimit/T cell rejuvenation

NewLimit identified 11 additional transcription factor sets that restore youthful function in aged T cells while testing over 4,000 sets across hepatocytes and T cells. The company also achieved a 100-fold reduction in computational requirements for payload design, improving efficiency of searching the vast space of possible transcription factor combinations.

• 11 new TF sets found to restore youthful function in aged T cells after screening over 4,000 combinations.
• Bayesian generative process achieved 100-fold reduction in compute requirements for payload design modeling.
• Efficiency gains enable faster exploration of approximately 10^16 possible transcription factor combinations without exhaustive computation.