insitro's AI-found liver drug CTRO-1013 cuts scarring markers in mice, not just liver fat

insitro/ML-driven target discovery

Silencing the gene IRS1 in the liver, a target insitro found with machine learning on human genetic data, cut liver fat by 45% and lowered scarring markers in obese mice, and held for 90 days in monkeys without upsetting blood sugar. The candidate is in the safety studies needed before a human trial.