TruAge by TruDiagnostic: status and timeline

TruAge

TruAge is a DNA methylation test that reports biological age through three independent epigenetic clocks and measures aging across 11 organ systems using 75+ methylation biomarkers.

DeployStage 4 of 5

Consumer test available; used by 30+ clinical research studies; L'Oreal partnership begun March 2025.

Updated 21 Mar 2025Checked 10 Oct0 updates this week

Milestones

No announced next step

TruDiagnostic foundedMar 2020Complete.
Public testing begins for TruAgeJul 2020Complete.
L'Oreal partnership announcedMar 2025Complete.
Recognized by Expert Consumers as best pace-of-aging test2026Complete.

Most important updates

L'Oreal announces strategic R&D partnership with TruDiagnostic to study epigenetics of skin and hair aging21 Mar 2025

Current obstacles

Causality still unclearEpigenetic clocks correlate with aging and disease, but reversing the methylation marks has not yet been shown to extend life in humans.
Clinical relevance unprovenUsing a test to guide therapy only works if moving the clock's number actually extends healthy lifespan, which has not been demonstrated.

Physics limits

Methylation changes with all cell typesA saliva sample contains cells from the mouth and respiratory tract, not organs like the heart or brain. The clock estimates their aging indirectly.
Age is not a single numberHuman aging involves hundreds of processes—inflammation, protein damage, mitochondrial failure, senescent cells. No single methylation measure captures all of them.

How it works

3 parts

Sample collection

Saliva test kit

TruAge comes as a mail-in saliva kit. The user collects saliva, mails it to TruDiagnostic's lab, and receives results online.

DNA methylation

Chemical marks on DNA

The lab measures where methyl groups sit on DNA, chemical tags that change with age. Different patterns point to different biological ages.

Three clocks

Comparing age estimates

TruAge calculates biological age three ways using different algorithms, then reports all three so the user sees whether they agree.

Spec sheet

Spec	TruAge
Total biomarkers in combo test	180+^R (reported)
DNA methylation sites measured per test	1,000,000+^R (reported)
Total data points in database	6+ trillion^R (reported)
Clinical research studies using TruAge	30+^R (reported)

^R reported by the company

Update log

1 update

Fri 21 Mar 2025

Major: L'Oreal announces strategic R&D partnership with TruDiagnostic to study epigenetics of skin and hair agingPressPartnership

About TruDiagnostic

The team behind TruAge

TruDiagnostic

Epigenetic clocks, DunedinPACE, OMICmAge, biological aging tests

TruDiagnostic runs epigenetic tests that measure biological age through DNA methylation patterns. Its TruAge test reports three aging clocks and organ-system aging across 11 body systems. L'Oreal and 80+ academic partners including Harvard use its tests in research.

Founded in March 2020 by Ryan Smith and Hannah Went, TruDiagnostic operates one of the world's largest DNA methylation databases.
In March 2025, L'Oreal announced a strategic R&D partnership to study how epigenetics governs skin and hair aging.
TruAge is used by 30+ clinical research teams and collaborates with 80+ academic partners.

trudiagnostic.com (opens trudiagnostic.com)Company profile →

Founded: 20206 yrs
Headquarters: United States
Status: Private
Valuation: private
Works in: LongevityInstitutes & funders
Coverage: 1 program · 1 updatelatest 21 Mar 2025checked 10 Oct
Partners: L'Oreal (opens loreal.com)
People: Ryan Smith (opens outliyr.com)Co-founderHannah Went (opens outliyr.com)Co-founderMatthew DawsonCEO

Spec

TruAge

Total biomarkers in combo test

180+^R (reported)

DNA methylation sites measured per test

1,000,000+^R (reported)

Total data points in database

6+ trillion^R (reported)

Clinical research studies using TruAge

30+^R (reported)