EnrollmentRecruit middle-aged healthy dogs
Dogs from existing Dog Aging Project network (54,900+ enrolled). Candidates 7+ years, 44-120 lbs, spayed/neutered, from diverse breeds and owners.
RandomizationBlind assignment to drug or placebo
Dogs randomly assigned rapamycin or placebo, dosed orally weekly. Owners and researchers blinded for one year dosing, then two years observation.
MeasurementAnnual health exams and lifespan tracking
Annual exams measure muscle, cognition, immune markers and other healthspan indicators. Study runs through 2029.