2027First preclinical whole-organ preservation and rewarming
Current obstacles
Cryoprotectant toxicityThe chemicals that prevent ice formation are toxic at the concentrations needed; designing safe molecules or better washout methods is the bottleneck.
Rewarming damageRewarming frozen organs without cracking is mechanically difficult; phase transition from glass to liquid is abrupt.
Physics limits
Organ complexityA whole organ has multiple cell types with different water and cryoprotectant permeability; some regions vitrify while others crystallize, making uniform preservation extremely difficult at scale.
Phase transition dynamicsWarming glass back to liquid water must happen smoothly across the whole organ; fast warming creates stress and cracking, slow warming gives time for ice to form in partially thawed regions.
How it works
3 parts
Perfusion
Filling the organ
The organ is perfused with a cryoprotectant solution that replaces water in cells and tissues, lowering the freezing point and preventing ice crystal formation.
Vitrification
Turning water to glass
Cooling to –130°C is slow enough and the cryoprotectant concentration high enough that water solidifies into amorphous glass instead of ice crystals.
Magnetic rewarming
Even heating throughout
Alternating magnetic fields generate heat throughout the organ uniformly, avoiding hot spots and temperature gradients that damage tissue.
Organ cryopreservation, vitrification, magnetic rewarming, transplant
Until Labs develops reversible organ cryopreservation technology using vitrification (turning water to glass without ice crystals) to extend the time donor organs remain viable for transplant from hours to weeks. The company is led by Laura Deming and Hunter Davis.
Founded June 2024; Laura Deming (CEO) and Hunter Davis (CSO). $58M Series A Sept 2025 for organ cryopreservation.
The Series A was led by Founders Fund with participation from Lux Capital and Field Ventures.