Oxford Nanopore announces PromethION Plus Flow Cell for ultra-high-output human genetics

Oxford Nanopore Technologies/PromethION

Oxford Nanopore revealed the PromethION Plus Flow Cell, designed to enable multiplexing multiple genomes per flow cell. The new ultra-high-output design targets cost-effective comprehensive genome and methylome sequencing, with limited release in Q4 2025 and broader availability in 2026.

• Optimized for 15–30 kb fragment libraries typical of human genome projects.
• Pathway toward genomes and epigenomes below $345 per sample at 30x coverage with future chemistry upgrades.
• Launched at ASHG 2025 with focus on population-scale discovery and high-throughput clinical sample analysis.
• Available in limited release Q4 2025, broader release in 2026.