Generate publishes Chroma, a generative model for protein design, in Nature

Generate Biomedicines

Generate Biomedicines published Chroma in Nature, a generative AI model for designing novel proteins with targeted biophysical, biological and therapeutic properties. The company released code and model weights freely to researchers.

• Chroma uses diffusion processes and neural architecture for sub-quadratic scaling in molecular systems.
• Validation: 310 designed proteins showed high expression, proper folding and favorable biophysical properties.
• Crystal structures of two Chroma-designed proteins matched predictions with ~1.0 Å backbone RMSD.
• Open-source release accelerates academic research; generative design complements structure prediction (AlphaFold).