AlphaFold 3, co-developed with Google DeepMind, published in Nature

Isomorphic Labs/AlphaFold 3

Google DeepMind and Isomorphic Labs published AlphaFold 3 in Nature. It predicts 3D structures of protein complexes with DNA, RNA, drugs and other molecules, extending AlphaFold beyond single proteins to the interactions relevant for drug design.

• AlphaFold 3 achieved 50% accuracy improvement over existing methods for protein-ligand interactions; some interactions showed double previous accuracy.
• First AI system to outperform physics-based tools for biomolecular structure prediction across all molecule types.
• AlphaFold Server launched free access; model code and weights released for academic use (as of November 2024).
• Isomorphic Labs used AF3 foundation for $3B+ in drug-discovery deals with Eli Lilly and Novartis.