Manufacturing scale-upMoving to registrational trials requires reliable large-scale manufacturing.
Physics limits
Blood-brain barrier permeability trade-offMolecules designed to cross the blood-brain barrier often have lower potency or selectivity; optimizing all three properties is challenging.
HER2 dependency for efficacyIAM1363 is effective only in tumors with HER2 alterations; tumors that lose HER2 expression or activate alternative pathways will develop resistance.
How it works
3 parts
AI Design
Machine learning predicts structure
Iambic's AI models predicted structures that bind all HER2 mutants and cross blood-brain.
AI-native drug discovery, chemistry automation, IAM1363, HER2
Iambic Therapeutics is an AI-native small-molecule drug developer founded in 2019 and headquartered in San Diego. It combines artificial intelligence with automated chemistry and biology experimentation to accelerate drug discovery, and is backed by NVIDIA and leading venture funds.
AI + automated chemistry for drug discovery. Founded 2019 by computational chemists Tom Miller and Fred Manby; raised $461.8M.