StoryPartnership

Eli Lilly signs deal worth up to $2.25B with Profluent for AI-designed gene editors

ProfluentProGen3 & OpenCRISPR

Lilly partnered with Profluent to design recombinases, enzymes that could insert entire genes into a patient's DNA rather than snip or swap letters. Lilly would pay up to $2.25 billion in milestones if all programs succeed.

  • Upfront payment, number of programs and target diseases were not disclosed.
  • Lilly has been building genetic medicine through acquisitions and a Boston research centre.
  • Inserting whole genes could treat diseases caused by many different mutations in one gene with a single editor.
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