by LivaNovaGB
Implantable neurostimulation for drug-resistant epilepsy and treatment-resistant depression. Pulse generator below clavicle delivers stimulation to vagus nerve via lead.
Market leader since 1997. Pursuing Medicare expansion for depression.
Updated Nov 2025Checked 10 Oct0 updates this week
2-inch generator placed below left collarbone. Lead runs through neck to left vagus nerve, like pacemaker placement.
Device sends mild pulses (20-30 Hz) to vagus nerve. Signals reach nucleus tractus solitarius and other brain regions.
Vagal signals trigger monoamine release in seizure and mood circuits. Reduces seizure frequency and alleviates depression over weeks.
Normal Mode delivers timed pulses. Magnet Mode lets patients trigger immediate stimulation when sensing a seizure.
| Spec | VNS Therapy System |
|---|---|
| Pulse generator dimensions | Roughly 2 inches in lengthR (reported) |
| Typical stimulation frequency | 20-30 HzR (reported) |
| Typical pulse generator longevity | 5-10 yearsR (reported) |
| Seizure reduction (focal onset) | 80% medianR (reported) |
| Depression benefit (RECOVER 24mo) | 51.6%R (reported) |
R reported by the company
LivaNova
VNS therapy epilepsy depression, cardiac devices
Publicly traded neuromodulation and cardiac surgery devices. VNS Therapy treats drug-resistant epilepsy and treatment-resistant depression by stimulating the vagus nerve.
