# Shift Bioscience unveils SB000, a single gene that rejuvenates cells as well as the Yamanaka factors without pluripotency

Canonical page: https://technooptimist.io/stories/shift-bioscience-unveils-sb000-a-single-gene-that-rejuvenates-cells-as-c1de8d80
Date: 9 Jun 2025
About: [Shift Bioscience](https://technooptimist.io/companies/shift-bioscience.md) · [SB000](https://technooptimist.io/longevity/sb000.md)
Original source: https://longevity.technology/news/single-gene-rejuvenation-target-promises-safer-cell-age-reversal/

Shift Bioscience disclosed SB000, a single gene found by a machine-learning screen of 1,500 candidates against its AC3 aging clock. In dermal and lung fibroblasts and keratinocytes it reversed age on several DNA-methylation clocks about as much as the Yamanaka factors, while the cells kept their identity and showed no stem-cell markers. The data are in a bioRxiv preprint; mouse studies come next.

## Key facts

- Found by screening 1,500 genes, scored on a transcriptomic clock trained on donors aged 1 to 87.
- Epigenetic age fell by more than 13 years on the PCHorvath2013 clock in keratinocytes.
- Treated fibroblasts kept normal shape and collagen output and formed no stem-cell colonies; OSKM pushed cells toward pluripotency.
- Not yet peer reviewed; next are more cell types and in vivo mouse studies.

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