# insitro's AI-found liver drug CTRO-1013 cuts scarring markers in mice, not just liver fat

Canonical page: https://technooptimist.io/stories/insitro-s-ai-found-liver-drug-ctro-1013-cuts-scarring-markers-in-mice-d675d0a0
Date: 8 Jun 2026
About: [insitro](https://technooptimist.io/companies/insitro.md) · [ML-driven target discovery](https://technooptimist.io/biotech/insitro-platform.md)
Original source: https://www.insitro.com/news/insitro-presents-new-data-demonstrating-its-ai-discovered-mash-candidate-shows-anti-fibrotic-signal-beyond-liver-fat-reduction-at-the-american-diabetes-association-86th-scientific-sessions/

Silencing the gene IRS1 in the liver, a target insitro found with machine learning on human genetic data, cut liver fat by 45% and lowered scarring markers in obese mice, and held for 90 days in monkeys without upsetting blood sugar. The candidate is in the safety studies needed before a human trial.

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