# First participant implanted in Newronika's ADVENT pivotal trial of adaptive versus conventional DBS

Canonical page: https://technooptimist.io/stories/first-participant-implanted-in-newronika-s-advent-pivotal-trial-of-838f02cd
Date: 30 Sep 2026
About: [Newronika](https://technooptimist.io/companies/newronika.md) · [AlphaDBS (αDBS)](https://technooptimist.io/neurotech/alphadbs.md)
Original source: https://www.webdisclosure.com/press-release/newronika-announces-first-participant-implanted-in-advent-pivotal-study-ruTYFzwkAYW

The first ADVENT participant received the αDBS implant on 21 September 2026 at San Gerardo dei Tintori hospital in Monza, Italy. ADVENT is a randomised, double-blind crossover trial: each patient gets both adaptive and conventional stimulation in random order, and the results are meant to support a US premarket approval application.

## Key facts

- Plans 104 adults with Parkinson's referred for bilateral subthalamic DBS
- Up to 18 sites in the US and EU; US enrolment expected soon
- Principal investigator at Monza: Prof. Giorgio Carrabba

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