# Aspen reports 12-month ASPIRO data: patient-derived dopamine cells improve Parkinson's symptoms without immunosuppression

Canonical page: https://technooptimist.io/stories/aspen-reports-12-month-aspiro-data-patient-derived-dopamine-cells-2a7330f8
Date: 18 Mar 2026
About: [Aspen Neuroscience](https://technooptimist.io/companies/aspen-neuroscience.md) · [Sasineprocel (ANPD001)](https://technooptimist.io/biotech/sasineprocel.md)
Original source: https://aspenneuroscience.com/aspen-neuroscience-announces-positive-12-month-data-from-its-aspiro-clinical-trial-in-a-late-breaking-oral-presentation-at-t/

In a late-breaking talk at AD/PD 2026, Aspen showed one-year results for the first eight patients given dopamine-neuron precursors grown from their own skin cells. Both dose groups gained roughly two hours a day of good symptom control and better motor scores, and PET scans showed the grafts survived. There were no serious surgical complications and no severe graft-induced movement problems.

## Key facts

- Good ON time +2.1 h (low dose) and +2.4 h (higher dose); motor score (OFF) -15.5 and -13.5 points.
- Quality-of-life (PDQ-39) improved 51.6% and 28.5%; several patients cut levodopa.
- Doses of 5 to 10 million cells per hemisphere, delivered under MRI guidance.
- Open-label and uncontrolled; improvements are numerical, not statistically tested.

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